Table 2

Effect of leptin on hydroxylation of testosterone in liver microsomes in obese (ob/ob) and lean (Ob/?) mice

Hydroxylation	LC	LL	OC	OL
6α	282.33 (11.34) ^a	312.15 (18.63) ^a	129.46 (8.12) ^b	193.20 (12.25) ^c
6β	790.12 (31.66) ^a	832.10 (71.64) ^a	929.08 (51.26) ^a	1105.87 (58.36 ^b
7α	419.90 (11.0) ^a	411.80 (28.28) ^a	799.15 (36.61) ^b	501.58 (16.46) ^c
16α	217.37 (9.91) ^a	256.74 (24.44) ^a ^b	278.19 (11.51) ^b	237.21 (9.83) ^a ^b

Data are expressed as means of nine replications for each treatment. Activities are expressed as pmoles per minute per milligram protein. Numbers in parentheses represent S.E.M. Similar lowercase letters represent means within an activity that are not statistically different by LSD (p ≤ .05). Mice were i.p. injected with PBS (100/μl/mouse) or leptin (100/μg/mouse) for 15 days before euthanasia. LC and OC represent lean and ob/ob mice injected with PBS and LL and OL represent lean and ob/ob mice injected with leptin.