Table 1

Pharmacokinetic data for flunitrazepam, cocaine, and nicotine

Drug	Dose	AUC	T_1/2	Total Drug in Hair (ng/mg Hair)		Incorporation Index
Drug	Dose	AUC	T_1/2	C57 (n = 4)	Balb/C (n = 4)	C57	Balb/C
		ng·h/μl	h
Flunitrazepam	1 mg/mg	12.57	16.18	0.89 ^1-a	0.14	0.07 ^1-a	0.01
Nicotine	10 mg/kg	8.03	1.43	0.34 ^1-a	0.025	0.04 ^1-a	0.003
Cocaine	4 mg/kg	20.52	2.89	1.08 ^1-a	0.06	0.05 ^1-a	0.003

AUC and T_1/2 values are mean of four animals. Incorporation index is total drug in hair divided by AUC (afterNakahara et al., 1996).

↵1-a Significantly greater than Balb/C results by one-way ANOVA with significance assumed at p < .01.