Table 1

Total amounts of bosentan and drug-related material excreted into urine and feces following a single oral dose of 500 mg of 14C-labeled bosentan and following a single i.v. dose of 250 mg of14C-labeled bosentan

SubstanceIntravenousOral
UrineFecesUrineFeces
Total radioactivity5.292.92.894.5
Bosentan0.93.70.130.2
Ro 48-50331.947.51.134.6
Ro 64-10561.017.70.513.2
Ro 47-86340.26.40.16.7
Minor metabolites0.58.00.35.1
Unknown0.69.60.74.7

Data are presented in percent of dose administered.