Table 3

Pharmacokinetic parameters of the metabolites Ro 48-5033 and Ro 47-8634 following a single oral dose of 500 mg of 14C-labeled bosentan and following a single i.v. dose of 250 mg 14C-labeled bosentan

h μg/l μg · h/l h % %
Ro 48-5033 oral dose
 Intravenous dose
Ro 47-8634 oral dose
 Intravenous dose
  • 3-a Relative to bosentan.