Table 3

Pharmacokinetic/pharmacodynamic parameter estimates3-a

ParameterControlGF120918
k 10(min−1)0.0184  ± 0.00340.0185  ± 0.0072
V (l/kg)5.95  ± 1.725.79  ± 1.75
k 12(min−1)0.164  ± 0.1420.117  ± 0.105
k 21 (min−1)0.590  ± 0.1600.263  ± 0.1983-150
EC50 (μM)0.0751  ± 0.03750.0538  ± 0.0387
γ3.55  ± 0.232.75  ± 1.42
AUE (%MPR · h)70.5  ± 16.9153  ± 38.23-150

  • ↵3-a Mean ± S.D.; n = 3 per treatment.

  • ↵3-150  p < .05 (unpaired t test).