NVP pharmacokinetic parameters after autoinduction
| Subject no. | ka1-a h−1 | k h−1 | T1/2 h | CL/F liter/h | V/F liter | Css μg/ml |
|---|---|---|---|---|---|---|
| 1 | 1.44 | 0.039 | 17.6 | 3.49 | 88.8 | 4.8 |
| 2 | 2.76 | 0.035 | 19.6 | 2.45 | 69.3 | 6.8 |
| 3 | 2.04 | 0.042 | 16.5 | 4.61 | 109.6 | 3.6 |
| 6 | 5.00 | 0.031 | 22.4 | 3.77 | 121.8 | 4.4 |
| 7 | 4.54 | 0.027 | 25.9 | 1.77 | 66.1 | 9.4 |
| 9 | 2.75 | 0.032 | 21.4 | 3.39 | 105.0 | 4.9 |
| 10 | 4.07 | 0.033 | 20.8 | 2.91 | 87.3 | 5.7 |
| 11 | 2.91 | 0.044 | 15.7 | 3.89 | 88.1 | 4.3 |
| Mean | 3.19 | 0.036 | 20.01-b | 3.29 | 92.0 | 5.5 |
| SD | 1.24 | 0.006 | 3.4 | 0.89 | 19.3 | 1.9 |
| CV% | 38.8 | 16.7 | 16.9 | 27.1 | 20.9 | 33.8 |
↵1-a ka, first-order absorption rate constant;k, first-order elimination rate constant;T1/2, half-life derived from k(T1/2 = ln 2/k), Cl/F, apparent clearance, V/F, apparent volume of distribution;Css, calculated average steady-state concentration with NVP 200 mg twice a day after autoinduction.
↵1-b The harmonic mean NVP T1/2 was 19.3 ± 3.2 h.