Table 3

Major radioactive components in (0–24 h) rat bile (percentage of chromatogram) after single and multiple oral dose administration of 10 mg/kg [14C]AT

Sample Time, DayApproximate Retention Time and Component Number
8 (1)123-a (2)403-b(3)683-c (4)703-d (6)893-e(7)90f(8)Total
15.8111.528.611.118.81.051.0578
82.018.2322.68.5123.61.571.9969
152.979.3728.611.815.11.241.3971

  • ND, not detected. Retention time given in minutes. Values in parentheses are component numbers.

  • ↵3-a Glucuronide conjugate of ortho-hydroxy AT.

  • ↵3-b para-hydroxy AT.

  • ↵3-c ortho-hydroxy AT.

  • ↵3-d AT.

  • ↵3-e β-Oxidized AT.