Table 1

Total MON metabolism (% of metabolized substrate/mg protein × 30 min) in liver microsomes from rats untreated or pretreated with PB, PCN, or DEX

Source of MicrosomesExtent of MON Metabolism (%)
UT4.4  ± 0.6
PB11.4  ± 0.2
PCN20.8  ± 0.2
DEX42.9  ± 1.3

Microsomes, buffer containing an NADPH · generating system, and 0.25 mM MON were incubated for 30 min; reactions were stopped with methanol, and the amount of MON was determined by HPLC as described inMaterials and Methods.

  • Values are means ± S.E. of four to six incubations.