Enzymatic constants of zopiclone metabolism
| Medium CYP3A Activity Liver Sample | Lowest CYP3A Activity Liver Sample | |
|---|---|---|
| ND-Z | ||
| V m (pmol/min/mg) | 45 ± 1 | 5.6 ± 0.1 |
| K m (μM) | 78 ± 5 | 98 ± 5 |
| Intrinsic clearance (μl/min/mg) | 0.58 | 0.06 |
| NO-Z | ||
| V m (pmol/min/mg) | 54 ± 5 | 15.4 ± 0.6 |
| K m (μM) | 84 ± 19 | 85 ± 9 |
| Intrinsic clearance (μl/min/mg) | 0.64 | 0.18 |
Experiments were performed on two liver samples chosen for their predetermined CYP3A activity: one with a medium CYP3A activity, and the other for its lowest CYP3A activity.