Table 1

Pharmacokinetic parameters of CZN in control and LPS-treated rats after an i.v. bolus dose of CZN (15 mg/kg)

ParametersControlLPS
Cls (ml/min)3.51  ± 0.242.3  ± 0.581-150
Half-life (min)30.5  ± 1.7881.4  ± 17.41-150
Vss (l/kg)0.39  ± 0.040.66  ± 0.121-150
Cli (ml/min)35.3  ± 4.0410.2  ± 2.361-150
0.1  ± 0.010.22  ± 0.041-150
  • Data are expressed as means ± S.D. of n = 7 animals.

  • 1-150p < .05