Table 3

Estimates of relative contribution of CYP enzymes to fluoxetine N-demethylation in human liver microsomes using recombinant CYP intrinsic clearance data

CYP EnzymeCYP Content3-aEstimated Percentage Contribution
(R)-Fluoxetine(S)-FluoxetineRacemic Fluoxetine
CYP1A2451.83.72.4
CYP2B6390.200.220.19
CYP2C996632843
CYP2C19192.74.13.0
CYP2D610152520
CYP3A4108183932
CYP3A51.00.060.110.07
  • 3-a  CYP content: picomoles of specific CYP enzyme per milligram of human liver microsomal protein as listed in Table 2 from Rodrigues (1999).