Table 2

AUC(0–t) of Oxo and CA in rats after i.v. or p.o. administration of S-1 at a dosage of 5 mg/kg

Administration RouteAUC(0–t)2-a
OxoCA
μg · h/ml
i.v. administration7.180.01
p.o. administration1.780.58
  • 2-a  AUC(0–t), determined from the mean plasma concentrations of Oxo and CA from groups of three rats per time point.