IC50 values for inhibition of bupropion hydroxylation by a series of antidepressants, including SSRIs
| Liver Sample | IC503-a Value | ||||||
|---|---|---|---|---|---|---|---|
| Sertraline | Desmethylsertraline | Fluoxetine | Norfluoxetine | Paroxetine | Nefazodone | Fluvoxamine | |
| HLM1 | 3.5 | 20.8 | 90 | 6.4 | 1.9 | 35.7 | 7.8 |
| HLM3 | 0.8 | 14.9 | 56 | 3.3 | 1.4 | 31.4 | 5.8 |
| HLM4 | 5.4 | 18.6 | 52.2 | 4.4 | 1.4 | 19.9 | 5.3 |
| HLM5 | 3.1 | 25.4 | 39.6 | 2.8 | 1.7 | 14.7 | 5.4 |
| Mean3-b | 3.2 | 19.9 | 59.5 | 4.2 | 1.6 | 25.4 | 6.1 |
| S.E.3-c | 0.9 | 2.2 | 10.8 | 0.8 | 0.1 | 4.9 | 0.6 |