Table 1
Kinetic parameters of amiodarone N-deethylase activity in human liver microsomes
HLG
K
M
V
max
μM
pmol/min/pmol
CYP
1
19.4
1.0
4
26.4
1.3
6
32.6
1.0
7
38.6
0.9
10
38.2
2.6
11
34.6
0.6
Mean ± S.D.
31.6 ± 7.5
1.2 ± 0.7