Table 1

Basal coumarin 7-hydroxylase activities in human hepatocytes (n = 16)

Biopsy NumberSexAgeViabilityCOH Activity1-a
years % pmol/mg/min
BH334Female67959.9  ± 1.0
BH338Female33991.0  ± 0.3
BH339Male75923.0  ± 0.1
BH340Female5696
BH342Male62893.7  ± 0.1
BH346Male369514.5  ± 2.8
BH348Female679720.1  ± 1.2
BH350Male68973.2  ± 0.6
BH351Female82924.0  ± 1.9
BH352Male78915.2  ± 0.3
BH354Female35983.2  ± 0.5
BH357Male72955.3  ± 0.7
BH358Female62899.6  ± 2.6
BH370Male32902.4  ± 0.5
BH373Male56891.2  ± 0.1
BH378Female3798
  • 1-a  COH activity was measured at 72 h of culture.