Table 3

Effect of murine in vivo inducers/depressors on COH activity in human and mouse hepatocytes

Treatment	Time	Human Hepatocytes		Murine Hepatocytes
Treatment	Time	Concentration	Activity	Concentration	Activity
	h		% of control		% of control
Phenobarbital	48	1 mM	84 ± 7	1.5 mM^3-b	380 ± 30^3-c
		2 mM^3-a	104 ± 11
	72	1 mM	223 ± 17^3-c		ND^3-d
Rifampicin	48	50 μM^3-b	82 ± 18	10 μM^3-a	320 ± 14^3-c
	72	25 μM	114 ± 11		ND
Pyrazole	48	10 mM^3-a	760 ± 46^3-c	10 mM^3-a	460 ± 61^3-c
Cobalt chloride	48	100 μM^3-a	90 ± 22	10 μM²	100 ± 75
		200 μM	63
	72	100 μM	188 ± 6^3-c		ND
		200 μM	182 ± 28^3-c
Griseofulvin	48	100 μM	99 ± 24	100 μM	604 ± 164^3-c
		200 μM^3-a	141 ± 25
	72	100 μM	156 ± 32		ND
Aminotriazole	48	200 μM^3-b	117 ± 13	100 μM^3-a	100 ± 35
		2 mM^3-a	171
	72	200 μM^3-b	182 ± 13^3-c
Thioacetamide	48	50 μM^3-b	82	10 μM^3-a	70 ± 89
Clofibric acid	48	500 μM^3-a	85 ± 12	500 μM^3-a	80 ± 51

↵3-a Concentrations close to the highest nontoxic concentration of the compound.
↵3-b Concentrations below the highest nontoxic concentration of the compound.
↵3-c P < .05.
↵3-d ND, not determined.