Table 8

Stimulation of PON1 type Q and R hydrolytic activities by dilauroyl PC

Substrate% Stimulation
PON1 Type Q8-aPON1 Type R8-b
Phenyl acetate48.259.9
γ-Butyrolactone68.937.3
Undecanoic-δ-lactone40.431.1
ɛ-Caprolactone22.723.8
Homogentisic acid lactone61.716.6
2-Coumaranone35.05.7
Dihydrocoumarin41.1−17.1

Percent stimulation is calculated from the mean value of duplicate assays.

  • ↵8-a  PON1 type Q activity = 52.5 μmol/min/ml enzyme preparation (phenyl acetate as substrate).

  • ↵8-b  PON1 type R activity = 47.4 μmol/min/ml enzyme preparation (phenyl acetate as substrate).