Molar ratios of concentrations of accessory proteins (OR or cytochromeb5) and concentrations of CYPs 1A2, 2B6, 2C19, 3A4, or 2D6 in human liver microsomes, and commercially available lymphoblast microsomes containing cDNA-expressed cytochromes
| CYP | OR:CYP Molar Ratio | Cytochromeb5:CYP Molar Ratio | ||
|---|---|---|---|---|
| Human Liver Microsomes | Lymphoblast Cell Microsomes | Human Liver Microsomes | Lymphoblast Cell Microsomes | |
| 1A2 | 3.5; (0.9–19.6); [2.6–4.2] | 0.038 | 18.8; (5.5–85.4); [15–24.8] | 0.65 |
| 2B6 | 1.54; (0.58–33); [0.8–19.5] | 0.054 | 7.13; (3.3–213); [4.2–102.2] | 0.56 |
| 2C19 | 3.9; (2.1–21.7); [2.4–4.4] | 0.162 | 20.9; (11.3–50.7); [14.7–25.7] | 2.4 |
| 3A4 | 0.25; (0.12–16.3); [0.21–0.41] | 0.455 | 1.18; (0.67–93.1); [0.93–2.9] | 1.19 |
| 2D6 | 5.53; (2.4–14.6); [3.7–10.8] | 1.49 | 34.0; (10.2–58.1); [26.2–46.8] | 0.53 |
Median values are presented (in boldface) for human liver microsomes with the range of values in parentheses and interquartile range in brackets (n = 12 for CYPs 1A2, 2B6, and 3A;n = 10 for CYP2C19, with poor metabolizer livers L11 and L12 excluded; n = 11 for CYP2D6, with poor metabolizer liver L8 excluded).