Table 1

Effect of acetonitrile and carbonyl-containing solvents on HL microsomal tolbutamide hydroxylation

SolventConcentration% of Control (% CV)
%
Acetonitrile1127  (4)
2178  (1)1-150
4187  (8)1-150
6149  (3)
Acetone1102  (8)
2175  (12)1-150
4190  (12)1-150
6171  (9)1-150
2-Butanone1105  (4)
2129  (14)
4113  (14)
676  (13)1-150
3-Pentanone1117  (5)
2105  (10)
431  (18)1-150
617  (12)1-150
  • 1-150  Significantly different from control lacking solvent (P < .05, Student's t test).