Description | Symbol | TM | SFM |
---|---|---|---|
Oral dose | Dosep.o. | 1001-a | 1001-a |
i.v. dose | Dosei.v. | 1001-a | 1001-a |
Compartment volumes (ml) | |||
Reservoir | VR | 2001-a | 2001-a |
Intestinal tissue | Vint | 31-b | |
Enterocyte layer | Ven | 0.31-c | |
Serosa and other tissues | Vs | 2.71-d | |
Intestinal blood volume | Vint,b | 1.621-b | |
Enterocyte blood | Ven,b | 0.1621-c | |
Serosal blood | Vs,b | 1.4581-d | |
Flow rate (ml/min) | |||
Intestinal blood | QI | 81-a | |
Mucosa blood to enterocyte layer | Qen | 0.81-e | |
Serosa and other tissue blood | Qs | 7.21-f | |
Clearances (ml/min) | |||
Drug transport clearance | CLd | 0.5 or 50 | 0.5 or 50 |
Metabolic intrinsic clearance | CLm | 0.1 to 501-g | 0.1 to 50 |
Secretory intrinsic clearance | CLsec | 0 to 501-g | 0 to 50 |
Absorption rate constant (min−1) | ka | 0.01 to 101-g | 0.01 to 10 |
Luminal degradation rate constant (min−1) | kg | 0.51-g | 0.5 |
↵1-a Assigned parameters.
↵1-b Value estimated based on Harrison and Gibaldi (1977) where 10 ml was used for a 360-g rat (including cecum and stomach) and the average intestinal weight = 3 g (ref. Doherty and Pang, 2000).
↵1-c Value associated with the designated flow to the enterocytes (0.1 × QI).
↵1-d Value associated with the designated flow to the serosal and other tissue layer (0.9 × QI).
↵1-e Qen = 0.1 × QI(assigned).
↵1-f Qs = 0.9 × QI(assigned).
↵1-g Parameters varied during simulations.