Table 2

Analytical solutions based on the traditional intestinal model for the CL_I, AUC, and availabilities (F_sys, F_I), when metabolism occurs only within the intestinal tissue

	With Luminal Secretion	Without Luminal Secretion
CL_others > 0
AUC_R,i.v.
AUC_R,p.o.
CL_t
CL_I
F_sys
F_I ^2-a
CL_others= 0
AUC_R,i.v.
AUC_R,p.o.
CL_I ^2-b, F_sys, F_I	Same as above	Same as above

Solutions for the SFM were similar to those shown below, with the exception that Q_I was Q_en.

↵2-a F_I = F_sys/ F_abs where F_abs = k_a/( k_a+ k_g).
↵2-b CL_I equals the total clearance CL_t when CL_others = 0.