Fitted parameters from the simultaneous fitting of systemic and intraduodenal data of M and M3G from the recirculating, vascularly perfused rat small intestine with the SFM (Fig. 2B), compared to those obtained previously according to the TM (Fig. 2A)3-a
| TM | SFM | ||
|---|---|---|---|
| Parameters | Fitted Values | ||
| CL1 (ml/min) | 0.513 ± 0.077 | CLd1(ml/min) | 1.73 ± 0.75 |
| CL2 (ml/min) | 0.0232 ± 0.010 | CLd2(ml/min) | 0.207 ± 0.14 |
| CL3 (ml/min) | 0.0714 ± 0.087 | CLsec (ml/min) | 0.117 ± 0.36 |
| CL4 (ml/min) | 0.191 ± 0.271 | CLa(ml/min) | 0.051 ± 0.166 |
| CL5 (ml/min) | 03-b | CLh(ml/min) | 03-b |
| CL6 (ml/min) | 03-b | CLg(ml/min) | 03-b |
| CL7 (ml/min) | 0.253 ± 3.08 | CLsec,M3G (ml/min) | 0.017 ± 0.031 |
| CL8 (ml/min) | 0.0323 ± 0.74 | CLa,M3G(ml/min) | ∼0 |
| CL9 (ml/min) | ∼0 | CLd1,M3G(ml/min) | 4.82 ± 63 |
| CL10 (ml/min) | 0.688 ± 3.97 | CLd2,M3G (ml/min) | 1.21 ± 15.4 |
| CL11 (ml/min) | 0.0210 ± 0.010 | CLm(ml/min) | 0.0215 ± 0.037 |
| CL12 (ml/min) | 0.0651 ± 0.085 | CLGIT (ml/min) | 0.0017 ± 0.006 |
| fG | 0.024 ± 0.033 | ||
| F abs 3-c | 0.75 | Fabs 3-c | 0.97 |
| Weighting | 1 | Weighting | 1 |
| r2 | 0.997 | r2 | 0.999 |
| MSC3-d | 4.59 | MSC | 5.51 |
| RSS | 389 | RSS | 169 |
↵3-a Data for i.v. (n = 4) and intraduodenal (n = 4) dosing of M were fitted simultaneously with mass balanced equations shown in the for the SFM and compared to the fitted results of Doherty and Pang (2000)for the TM.
↵3-b Assigned.
↵3-c Calculated as CL4/(CL4 + CL12) or CLa/( CL a +CLGIT).
↵3-d Model Selection Criterion—the greater the number, the better the fit.