Table 3

Cumulative percentage of the dose excreted as M-1 (acyl glucuronide) and M-2 carboxylic acid metabolite in urine collected 0 to 12 h after dosing

Subject No.Cumulative Dose Excreted as M-2 (0–12 h) Carboxylic Acid MetaboliteCumulative Dose Excreted as M-1 (0–12 h) Acyl Glucuronide
%
00113.30.525
00213.61.82
10126.11.56
930217.82.08
10315.60.860
10428.61.62
10513.41.39
10621.91.62
Mean ± S.E.18.8 ± 2.11.48 ± 0.15