Table 2

Summary of cumulative recovery of radioactivity from cancer patients after i.v. administration of [14C]CPT-11

Percent of Radioactive Dose Excreted
UrineFecesBileTotal
Patient
 127.767.0N.D.94.7
 232.268.1N.D.100.3
 343.854.2N.D.98.0
 430.661.5N.D.92.2
 548.214.230.192.5
 621.774.9N.D.96.6
 733.360.8N.D.94.1
 835.859.1N.D.94.8
Mean (±) S.D. (n = 7)32.2 ± 6.963.7 ± 6.8N.D.95.8 ± 2.7
% CV21.410.8N.D.2.8

Differences across gender were not significant. Bile-exteriorized Patient 5 was omitted from calculation of means.

  • N.D., not done, only patient 5 was bile-exteriorized.