Fa | 1 (assumed) | ||
k a | 0.05/min−1 | Desgranges et al., 1986 | |
Q | 40 ml/min/kg | ||
K p | 1 (assumed) | ||
fb | 0.17 | fb = fu/RB, RB = 1 was assumed. | |
CLtot | 2.8 ml/min/kg | CLtot = Dose/AUC (AUC: 1175 μM · hr) | Desgranges et al., 1986 |
CLint | 18 ml/min/kg | according to well-stirred model | |
Vliver | 40 ml/kg | ||
Vpv | 1 ml/kg | ||
k e | 0.0015/min−1 | calculated from t 1/2 = 7.5 hr | Desgranges et al., 1986 |
Vsys | 1860 ml/kg | calculated from Vsys= CLtot/k e − Vliver |