Table 2

Pharmacokinetic parameters of BVU (200 μmol/kg dose) in rats

Fa 1 (assumed)
k a 0.05/min−1 Desgranges et al., 1986
Q40 ml/min/kg
K p 1 (assumed)
fb 0.17fb = fu/RB, RB = 1 was assumed.
CLtot 2.8 ml/min/kgCLtot = Dose/AUC (AUC: 1175 μM · hr) Desgranges et al., 1986
CLint 18 ml/min/kgaccording to well-stirred model
Vliver 40 ml/kg
Vpv 1 ml/kg
k e 0.0015/min−1 calculated from t 1/2 = 7.5 hr Desgranges et al., 1986
Vsys 1860 ml/kgcalculated from Vsys= CLtot/k e − Vliver