Table 5

Prediction of in vivo interaction between tolbutamide and sulfonamides

KiIu/KiPredicted AUC RatioReported AUC Ratio
μM
Sulfaphenazole0.30688.94.85.35-a
Sulfadiazine46.23.422.6
Sulfamethizole53.41.191.81.65-b
Sulfisoxazole1612.002.1
Sulfamethoxazole2830.661.5
Sulfapyridine4270.241.2
Sulfadimethoxine4360.0901.1
Sulfamonomethoxine>500NCNC

  • ↵5-a Veronese et al., 1990b.

  • ↵5-b Lumholtz et al., 1975.

  • NC: Not calculated.