Fold Induction | ||
---|---|---|
DEX | RIF | |
No added receptor | 2.2 | 13.0 |
+ hGR | 3.9 | 15.8 |
+ PXR | 3.2 | 26.7 |
+ hGR + hPXR | 5.2 | 33.1 |
Xenobiotic fold induction values were calculated as described inMaterials and Methods and are the mean of eight determinations. Maximally inducing concentrations of DEX and RIF (50 μM) were used as previously determined (Ogg et al., 1999).