Kinetics of DPDS and PM in an isolated perfused rat liver
| DPDS | PM | |
|---|---|---|
| Half-life (min) | 4.2 ± 0.5 | 5.2 ± 0.5 |
| Clearance (ml/min) | 388 ± 52 | 50.6 ± 14.2 |
| AUC (min · μg/ml) | 54 ± 6 | 481 ± 110 |
| Volume of distribution (ml) | 2282 ± 113 | 350 ± 56.8 |
Twenty milligrams of DPDS or PM was added to the liver perfusion medium. Results are means of four replicate experiments ± S.E.