Table 1

Kinetic parameters for uptake of enalapril by isolated rat hepatocytes

Experiment	K_m^1-a	V_max^1-a
	μM	nmol/min/10⁶ cells
Whole liver cells with sodium (n = 5)	344 ± 52^1-b	11.0 ± 1.5
Whole liver cells without sodium (n = 4)	446 ± 179	11.6 ± 4.2
Periportal cells with sodium (n = 4)	461 ± 117	9.5 ± 2.0
Perivenous cells with sodium (n = 4)	441 ± 50	10.4 ± 2.0
ANOVA	NS^1-c	NS

The weighting scheme of 1/(observation)² was optimal, and was used for fitting with the program Scientist (v.2; Micromath Scientific Software, Salt Lake City, Utah)

↵1-a Kinetic constants obtained from fitting to a single saturable component model (eq. 1)
↵1-b S.D. of the mean
↵1-c Not significant (P > .05)