MCF-dosed Sprague-Dawley rats
| MCF-Dosed Sprague-Dawley Rat | CPPA | MCF-Glucuronide | Nac-OH3-a | Nac-Acid | CPPA/Mercapturates | CPPA + Mercapturates/MCF-Glucuronide |
|---|---|---|---|---|---|---|
| 1 | 765 ± 5 | 3890 ± 70 | 380 ± 4 | 118 ± 0 | 1.5 | 0.3 |
| 2 | 600 ± 13 | 2350 ± 40 | 202 ± 3 | 72 ± 1 | 2.2 | 0.4 |
| 3 | 1180 ± 24 | 7000 ± 86 | 732 ± 6 | 258 ± 4 | 1.2 | 0.3 |
| Average | 848 ± 244 | 4413 ± 1934 | 438 ± 220 | 149 ± 79 | 1.6 ± 0.4 | 0.3 ± 0.0 |
All metabolites are reported as a percentage of excreted felbamate. Mercapturates = Nac-OH + Nac acid combined.
↵3-a Nac-OH,N-acetyl-S-(2-phenylpropan-3-ol)-l-cysteins; Nac-acid, N-acetyl-S-(2-phenylpropanoic acid)-l-cysteine.