Table 5

Radiometabolite quantification in plasma from human subjects after administration of [14C]rosiglitazone to four volunteers (mean)

Metabolite No.MetabolitePercentage of Plasma Radioactivity
1 h4 h8 h24 hDay 4
8-mg oral dose [14C]rosiglitazone
 4 N-desmethyl-para-O-sulfate0231011
8 ortho-O-sulfate02212
10 para-O-sulfate1846606580
12 N-desmethyl (SB 237216)11156174
14rosiglitazone71341920
Total identified10099909597
2-mg i.v. dose [14C]rosiglitazone
4 N-desmethyl-para-O-sulfate0351012
8 ortho-O-sulfate01210
10 para-O-sulfate944606586
12 N-desmethyl (SB 237216)51617192
14rosiglitazone86341530
Total identified101989998100