Table 1

Effect of mibefradil, ketoconazole, and PSC833 on P-gp determined using digoxin transport in Caco-2 cells, and CYP3A-mediated nifedipine oxidase activity in human liver microsomes

IC50Ki
P-gpCYP3ACYP3A
μM μM
Mibefradil1.60.800.6
Ketoconazole1.40.150.05
PSC 8330.111016

Each experiment was performed on at least two different experimental days.