Table 4

Effect of PPP on the enzymatic activities of several different P450s

P450 IsozymePPP% Activity Remaining
0 min10 min
P450 2C90.110072
P450 2D60.019265

Assay conditions were as described in Experimental Procedures. No effect was seen on the activities of P450 1A1, 1A2, and 3A2 with PPP concentrations of 0.1 to 1.0 mM or P450 2E1 with PPP concentrations of 0.01 to 0.1 mM. The data represent the average from two different experiments. Values differed by less than 10%.