Table 2

Signals (arbitrary units) obtained from the DNA arrays for various drug-metabolizing enzymes

	Gene	Controls (n = 10)		MS Baseline (n = 10)		MS Post-IFN (n = 10)		P Value
	Gene	Mean	CV	Mean	CV	Mean	CV	Disease Effect	IFN Effect
			%		%		%
UGT 2B4 precursor, microsomal	UGT 2B4	1.4 × 10²	28	1.7 × 10²	27	1.8 × 10²	52	.31	.54
UGT 2B10 precursor, microsomal		1.3 × 10³	23	1.5 × 10³	22	1.6 × 10³	23	.36	.19
UGT 2B15 precursor	UGT2B15	1.1 × 10³	52	1.1 × 10³	56	1.1 × 10³	73	.94	.68
COMT	COMT	2.4 × 10³	149	2.2 × 10³	157	1.9 × 10³	154	.88	.16
ThiopurineS-methyltransferase	TPMT	2.6 × 10²	44	2.7 × 10²	46	2.6 × 10²	40	.79	.70
Hydroxysteroid sulfotransferase	HSST2	1.1 × 10³	70	1.3 × 10³	76	9.4 × 10²	79	.48	.050
DHEA-preferring sulfotransferase	STD	2.2 × 10³	76	3.4 × 10³	92	2.5 × 10³	61	.27	.14
GST M2	GSTM2	6.2 × 10²	45	3.9 × 10²	46	4.4 × 10²	48	.16	.068
GST theta 2	GSTT2	4.9 × 10²	29	4.6 × 10²	36	4.5 × 10²	37	.078	.88
GST M4	GSTM4	1.3 × 10⁴	10	1.6 × 10⁴	47	1.7 × 10⁴	33	.85	.39
GST M3	GSTM3	4.7 × 10²	24	6.5 × 10²	46	5.0 × 10²	24	.59	.15
GST M5	GSTM5	2.4 × 10²	36	2.2 × 10²	90	1.8 × 10²	71	.85	.29
GST π-1	GSTP1	1.8 × 10²	12	1.6 × 10²	59	1.5 × 10²	28	.24	.80
GST A2	GSTA2	4.5 × 10²	11	4.7 × 10²	33	4.8 × 10²	28	.71	.85
GST θ-1		1.1 × 10³	50	5.8 × 10²	135	5.1 × 10²	110	.51	.39
GST A3	GSTA3	1.2 × 10³	101	1.3 × 10³	80	1.3 × 10³	71	.34	.71
Microsomal GST		1.8 × 10²	31	1.4 × 10²	38	1.6 × 10²	45	.11	.50
Microsomal GST 2	MGST2	2.0 × 10²	49	1.5 × 10²	60	1.5 × 10²	55	.40	.95
Microsomal GST 3	MGST3	7.3 × 10²	48	4.6 × 10²	73	4.7 × 10²	53	.20	.84
GST homolog		1.3 × 10⁴	71	1.1 × 10⁴	59	1.1 × 10⁴	56	.52	.38