Table 2

Effect of preincubation with GF120918 (60 min) on accumulation of Rh123 and digoxin in SC rat hepatocytes during incubation with HBSS or Ca2+-free HBSS

SubstrateTreatment Accumulation
HBSSCa2+-Free HBSS
pmol/mg of protein
Rh123Control157  ± 11130  ± 9
0.5 μM GF120918161  ± 18149  ± 16
2 μM GF120918143  ± 11137  ± 12
DigoxinControl34  ± 315  ± 1
2 μM GF12091835  ± 229  ± 2

Values represent mean ± S.E.M. of three independent experiments with quadruplicate incubations.