Table 2

Formation of (+)- and (−)-9-hydroxyrisperidone in cDNA-expressed microsomes at different concentrations of risperisone

RisperidoneSupersomes GENTEST
CYP2D6CYP3A4CYP3A5
(+)-9-OH(−)-9-OH(+)-9-OH(−)-9-OH(+)-9-OH(−)-9-OH
μM
0.250.32
0.50.61
10.95
51.75
101.85
252.00
502.35
1002.210.170.640.120.44
K m 1.40 ± 0.07
V max 2.21 ± 0.09

The rate of formation and Vmax is expressed in units of picomoles formed metabolite per minute and picomoles of P-450 andKm values as micromolar.

  • —, no metabolite was formed. OH, hydroxy.