Physiological parameters for calculation of intrinsic clearance in rats, dogs, and humans
| Rat | Dog | Human | |
|---|---|---|---|
| Microsomal protein per gram of liver (mg of protein/g of liver) | 44.8 | 77.9 | 48.8 |
| Liver weight per kilogram of body weight (g of liver/kg) | 40 | 32 | 25.7 |
| Liver blood flow (ml/min/kg) | 55.2 | 30.9 | 20.7 |
Reference: Iwatsubo et al., 1997b, Davies and Morris, 1993