Table 7

Specificity of mAbs anti-2C8, 2C9, and 2C19 for inhibition of diazepam N-demethylation

mAb/P450	2C8	2C9^*1	2C9^*2	2C18	2C19
Control Activity^7-a	0.94	1.36	1.12	0.62	2.57
mAbs anti-2C8
mAb 281-1-1	91	—^7-b	—	—	—
mAb 13-1-3	91	—	—	—	—
mAb 5-1-5	91	—	—	—	—
mAbs anti-2C9
mAb 763-15-5	—	89	90	—^7-c	—
mAb 592-2-5	—	82	88	81	—
mAb 5-7-5	—	94	93	93	93
mAb 292-2-3	—	—	91	—	—
mAb 1-68-11	83	93	95	84	94
mAbs anti-2C19
mAb 1-7-4-8	—	—^7-d	—^7-d	—	96
mAb 1-1-11	—	—^7-d	—^7-d	—	97
mAb 1-5-1-3	—	—^7-d	—^7-d	—	97

↵7-a Control activity is in namoles per minute per nanomoles of P450.
↵7-b —, <1 to 10% inhibition.
↵7-c At very high levels, mAb 763-15-5 inhibited 2C18 by 25% (see Fig. 2A).
↵7-d At very high levels, mAbs anti-2C19 inhibited P450 2C9*1 by 20% and 2C9*2 by 35% (see Fig. 2D).