Kinetic parameters for total metabolism of propranolol analogs by recombinant human CYP2D6
| Substrate | Kmave | kcat | kcat/Km |
|---|---|---|---|
| μM | min−1 | ||
| 2S-P | 3.90 | 66.5 | 17.1 |
| 2R-P | 1.50 | 37.7 | 25.1 |
| 2S-FP | 1.47 | 16.2 | 11.0 |
| 2S-DFP | 3.53 | 22.8 | 6.45 |
| 2S-TFP | 77.0 | 73 | 0.95 |
| 2S,4R-TFP | 33.5 | 45.4 | 1.36 |
| 2R-TFP | 30.7 | 58.4 | 1.90 |
| iPrMe | 0.39 | 26.5 | 68.1 |
| tBuMe | 0.19 | 13.1 | 68.2 |
| TFE | 42.4 | 36.6 | 0.86 |
| desOHP | 0.19 | 33.9 | 179 |
| desOHTFP | 7.20 | 38.9 | 5.40 |