Table 2

Pharmacokinetic parameters defining systemic disposition of SB-250231 in the monkey following intravenous, intraportal, and intraduodenal administration

Parameter	Intravenous	Intraportal	Intraduodenal^2-b
Parameter	Intravenous	Intraportal	Portal Samples		Systemic Samples
Dose (mg/kg)	1.39 ± 0.02	1.39 ± 0.02		2.68 ± 0.01
CL (ml/min/kg)	12.9 ± 4.70	—^2-a	—		—
AUC (min · μg/ml)	115 ± 48	42.0 ± 28.1	255, 228^2-b		101, 96.0^2-b
DNAUC (min · kg/l)	82.8 ± 34.1	30.5 ± 20.7	94.9, 85.0^2-b		37.6, 35.8^2-b
Vd_SS(l/kg)	0.855 ± 0.825	—	—		—
MRT (min)	58.7 ± 37.5	48.0 ± 12.3	—		74.5, 145^2-b
t½ (min)	60.9 ± 34.2	38.9 ± 4.5	—		65.6, 156^2-b
Eh (%)	—	35.0 ± 10.5	—		—
F (%)	—	—		31.7, 70.2^2-b

Data are presented as mean ± S.D. of three monkeys, unless otherwise noted.

CL, clearance; MRT, mean residence time.
↵2-a —, parameter not determined for this route of administration.
↵2-b One monkey demonstrated sampling difficulties during the intraduodenal leg of the experiment; the data from that animal are excluded for this study leg.