Table 1

Percentage of control activity of bupropion hydroxylation with microsomes incubated with inhibitor (10 and 100 μM)

InhibitorPercentage of Control Activity (without Inhibitor) at:
10 μM Inhibitor1-a100 μM Inhibitor1-b
Ritonavir300
Indinavir8784
Nelfinavir3126
Saquinavir9468
Amprenavir7649
Delavirdine9180
Nevirapine10090
Efavirenz356

  • ↵1-a  n = four different human livers.

  • ↵1-b  n = one human liver.