Table 2

Percentage of control activity of bupropion hydroxylation with microsomes preincubated with inhibitor versus microsomes not preincubated

InhibitorPercentage of Control Activity
With PreincubationNo Preincubation
Nelfinavir (1 μM)8771
Nelfinavir (10 μM)2337
Ritonavir (1 μM)9986
Ritonavir (10 μM)3929
Efavirenz (1 μM)6775
Efavirenz (10 μM)3035
Delavirdine (10 μM)8291
Delavirdine (100 μM)6780