Sulfating activities toward serotonin and its derivatives
| Substrate (10 μM) | Sulfating Activities | ||||
|---|---|---|---|---|---|
| ST1A5 (Human) | ST1A3 (Human) | ST1A1 (Rat) | St1a4 (Mouse) | ST1A8 (Rabbit) | |
| nmol/nmol/min [% of ST1A3 activity] | |||||
| Serotonin | 0.36 ± 0.06 [1205] | 0.03 ± 0.00 [100] | 0.09 ± 0.00 [293] | 0.10 ± 0.01 [323] | 0.07 ± 0.01 [241] |
| 5-Hydroxytryptophol | 0.36 ± 0.04 [13] | 2.79 ± 0.20 [100] | 5.59 ± 0.09 [200] | 2.27 ± 0.17 [81] | 2.59 ± 0.08 [93] |
| 5-Hydroxyindole | 0.59 ± 0.03 [6] | 10.24 ± 0.15 [100] | 10.39 ± 0.19 [101] | 9.33 ± 0.23 [91] | 10.82 ± 0.35 [106] |
| 6-HM | 1.84 ± 0.07 [39] | 4.70 ± 0.22 [100] | 3.95 ± 0.15 [84] | 3.41 ± 0.34 [73] | 3.94 ± 0.10 [84] |
| Harmol | 3.93 ± 0.13 [78] | 5.07 ± 0.03 [100] | 5.02 ± 0.18 [99] | 6.24 ± 0.24 [123] | 1.79 ± 0.09 [35] |
| HIAA | N.D. | N.D. | N.D. | N.D. | N.D. |
Assays were performed as described in Table 3. Each value represents mean ± S.D. (n = 3).
N.D., not detected (less than 10 pmol/mg/min).