Table 5

Comparison of the clearances for E1S and E1 in zonal hepatocytes

Parameters5-aDescriptionPeriportalPerivenous
μl/min/106 cells
CL Embedded Image Uptake clearance for E1S5-b 246282
P Embedded Image Uptake clearance for E1 14841463
CL Embedded Image Intrinsic clearance for E1S desulfation5-c 7255
CL Embedded Image Intrinsic clearance for sulfation of E1 5-d 3.213
CL Embedded Image Intrinsic clearance for glucuronidation, hydroxylation, and oxidation of E1 (other than sulfation of E1)5-e 328495
CL Embedded Image Intrinsic clearance for accumulation of E1S into vesicle0.660.49

  • ↵5-a  Values become ml/min/g of liver when multiplied by the factor (125/1000).

  • ↵5-b  Obtained as V Embedded Image / K Embedded Image + P Embedded Image .

  • ↵5-c  Obtained as V Embedded Image / K Formula .

  • ↵5-d  Obtained as V Embedded Image / K Embedded Image .

  • ↵5-e  Obtained as V Embedded Image / K Embedded Image .