Table 1

Kinetic parameters for the N2-glucuronidation of RG 12525 by human liver microsomes

Sample	K_m (RG 12525)	V_max	CL_int
	μM	nmol/min/mg	μl/min/mg
RPR-HL-10	16.6	4.38	264
RPR-HL-18	21.1	3.54	168
RPR-HL-20	19.9	5.94	298

Apparent K_m and V_max values were determined from linear regression analysis of Eadie-Hofstee plots using an integrated form of the Michaelis-Menten equation to minimize error in K_m (Segel, 1976).

HL, human liver.