Table 3

Correlation between 7-BROD activity pattern and standard agent sensitivity patterns

NSCNAMEMOAPCCp Value
2847518-Cl CYC AMP−0.4670.00017
8806MelphalanA7−0.4400.00043
253272Caracemide−0.4290.00062
167780AsaleyA7−0.4270.00067
34462Uracil nitrogen mustardA7−0.4240.00074
73754FlurorodopanA7−0.4240.00075
752ThioguanineDI−0.4210.00080
602668Carmethiozole−0.4160.00095
312887Fludarabine phosphate−0.4140.00100
3088ChlorambucilA7−0.4130.00103
  • MOA, mechanism of action, classified according to van Osdol et al. (1994) for those compounds whose MOA is known. A7, alkylation at N7 position of guanine; DI, agent incorporated into DNA.

  • Library: Ling Springer/Style: Drug Metab Dispos