Kinetic parameters of M1 and M2 formation by rat and human liver microsomes
| Microsomes | KM | Vmax | Vmax/KM | |||
|---|---|---|---|---|---|---|
| M1 | M2 | M1 | M2 | M1 | M2 | |
| μM | pmol/mg/min | μl/min/mg | ||||
| Rat | 87 ± 13 | 178 ± 31 | 139 ± 39 | 1286 ± 188 | 1.58 ± 2.23 | 7.22 ± 1.17 |
| Human | 312 ± 1371-a | 312 ± 571-a | 8.56 ± 1.091-a | 454 ± 681-a | 0.03 ± 0.011-a | 1.52 ± 0.931-a |
Values are mean ± S.D. of three individual liver microsomal preparations.
↵1-a Significantly different from rat values at p < 0.01.