Table 6

Pharmacokinetic parameters of midazolam and erythromycin

Midazolam		Erythromycin
Dose, substrate	9.69 μmol^6-a	Dose, inhibitor	681 μmol^6-a
f_b,s	0.05^6-a	f_b,i	0.78
K_m,s	3.7 μM^6-b	f_h,i	0.53
V_max,s(0)	2410 μmol/hr^6-b	F_a	1^6-c
V_d,s	20.2 liter^6-a	k_a	3.42 h⁻¹
K_p,s	13.2	K_m,i	88 μM^6-d
		V_max,i(0)	1960 μmol/h^6-d
		V_d,i	46.2 liter^6-e
		K_p,i	29.7
		k_deg	0.0578 h⁻¹
		k_inact	0.0655 min⁻¹
		K_i	81.8 μM

↵6-a Olkkola et al. (1993).
↵6-b Wandel et al. (1998).
↵6-c Assumed that F_ais 1 to avoid false negative prediction since F_a is unknown.
↵6-d Wang et al. (1997).
↵6-e Kroboth et al. (1982).