Pharmacokinetic parameters of midazolam and erythromycin
Midazolam | Erythromycin | ||
---|---|---|---|
Dose, substrate | 9.69 μmol6-a | Dose, inhibitor | 681 μmol6-a |
fb,s | 0.056-a | fb,i | 0.78 |
Km,s | 3.7 μM6-b | fh,i | 0.53 |
Vmax,s(0) | 2410 μmol/hr6-b | Fa | 16-c |
Vd,s | 20.2 liter6-a | ka | 3.42 h−1 |
Kp,s | 13.2 | Km,i | 88 μM6-d |
Vmax,i(0) | 1960 μmol/h6-d | ||
Vd,i | 46.2 liter6-e | ||
Kp,i | 29.7 | ||
kdeg | 0.0578 h−1 | ||
kinact | 0.0655 min−1 | ||
Ki | 81.8 μM |