Table 2

Pharmacokinetic parameters of cimetidine, itraconazole, erythromycin, and midazolam in rats

KpfpfHCHf/ Cpf
Cimetidine2-a 3.81  ± 0.660.80  ± 0.100.42  ± 0.101.94
Itraconazole2-b 16.6  ± 3.70.0034  ± 0.00020.0024  ± 0.000411.7  ± 2.6
Erythromycin29.7  ± 5.40.78  ± 0.080.53  ± 0.0320.8  ± 3.7
Midazolam13.2  ± 3.5

  • Values are means ± S.D. (n = 3–6).

  • ↵2-a  Cited from our report concerning the interaction between histamine H2 receptor antagonists and MDZ (Takedomi et al., 1998).

  • ↵2-b  Cited from our report concerning the interaction between itraconazole, ketoconazole, and MDZ (Yamano et al., 1999).