Parameters1-a | No Additional Drug | Teicoplanin | |
---|---|---|---|
1 μg/ml | 100 μg/ml | ||
PSu × 104(ml/min) | 46 ± 3 | 41 ± 11 | 13 ± 1 |
V c × 104 (ml) | 71 ± 4 | 77 ± 2 | 54 ± 1 |
k T(min−1) | 0.027 ± 0.003 | 0.024 ± 0.007 | 0.0073 ± 0.0004 |
t 1/2 (min) | 26 ± 3 | 36 ± 14 | 96 ± 5 |
K vitro (ml) | 0.10 ± 0.012 | 0.063 ± 0.007 | 0.032 ± 0.003 |
fuc | 0.028 ± 0.003 | 0.030 ± 0.006 | 0.019 ± 0.001 |
↵1-a Mean number of hepatocytes in the cell suspension was 0.83 × 106 cells (±0.02;n = 36); see text for definition of parameters.